"The brain hides its secrets.
The nose is the Rosetta Stone we use to unlock them"
SpikeWatch is the first platform to detect, interpret, and predict biological spike patterns in Alzheimer’s Disease, empowering precision intervention before decline accelerates.
"The nose. The Rosetta Stone of the brain.
Before the brain could think, it learned to sense — through the olfactory system, the original gateway to cognition and survival.
At 3DNasal, we decode this ancient pathway, mapping the Tribiome — the dynamic interaction between the nasal, gut, and skin microbiomes — and its impact on brain health.
By targeting the olfactory-brain axis, we are developing novel, precision therapies for neurodegenerative diseases like Alzheimer's and Parkinson's, aiming to treat the root causes, not just the symptoms.
3DNasal: where precision healthcare begins, at the first interface of life and thought."
"Others study the brain.
We hold the key to its Rosetta Stone."
Email: guy@neuroteg.com
Havard University: Are some cases of Alzheimer's disease caused by infection?
“A holistic approach to health, connecting your nasal, gut, and skin microbiomes for total wellness.”
🌟 NeuroMAIT-P™
Intercepting Alzheimer's Before It Begins
Our Mission
NeuroMAIT-P™ represents the next frontier in Alzheimer's prevention.
By combining NeuroMAIT-101(an immune-microbiome modulator) with NCT-503(a PHGDH disruptor), we deliver precision therapies directly through the nasal-brain axis.
Our goal: to intercept Alzheimer’s disease before it can start
Scientific Innovation
Using advanced nasal delivery, NeuroMAIT-P™ enhances MAIT cell function and stabilizes early gene regulation in the brain.
Our dual-action approach prevents the first molecular errors that lead to Alzheimer’s — well before classic damage like amyloid plaques or tau tangles appear.
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Technology Highlights
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Direct-to-brain nasal spray delivery
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MAIT cell immune priming to control neuroinflammation
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PHGDH DNA-binding inhibition without disrupting essential metabolism
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Precision targeting through Tribiome and Spatial Intelligence technologies
Why It Matters
Traditional therapies react after damage has occurred.
NeuroMAIT-P™ acts before symptoms ever emerge— protecting neural health at the source.
This is not just disease management — it’s disease interception.
Email: guy@neuroteg.com
WHY WORK WITH US
3DNasal Digital Twin: Revolutionizing Personalized Neurodegenerative Care
Email: guy@neuroteg.com
📚 References | NCT-503 and PHGDH Discovery
Study Overview:
Recent research using artificial intelligence revealed a hidden role for the PHGDHgene in Alzheimer's disease:
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PHGDH, traditionally known for its role in serine biosynthesis, also possesses an unexpected DNA-binding function.
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This hidden function disrupts gene regulation in the brain, contributing to disease progression.
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NCT-503, a small molecule inhibitor, selectively blocks this DNA-binding activity without affecting PHGDH’s normal enzymatic role, offering a new upstream target for Alzheimer's therapy.
🧠 Key Scientific Sources:1. Primary Research Study:
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Cell (2025)
Title:A Hidden DNA-Binding Function of PHGDH Drives Alzheimer's Progression
Summary:
AI-based analysis discovered PHGDH’s DNA-binding activity.
NCT-503 blocks this function selectively, protecting brain gene regulation.
Link to study
2. Scientific News Coverage:
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Neuroscience News (April 2025)
AI Uncovers New Genetic Cause of Alzheimer's Disease
Summary:
Treatment with NCT-503 in mouse models improved memory, reduced anxiety, and prevented early Alzheimer's-like changes.